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Phenotypes Associated with This Genotype
Genotype
MGI:2674160
Allelic
Composition
Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm3Wbm mutation (0 available); any Ctnnb1 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no homozygous embryos found after E9.5
• normal numbers of homozygotes through E7.5

embryo
• all embryonic cell layers present at E5.5
• after E7.5 apoptosis became prominent in embryonic ectoderm
• beta-catenin required in embryonic ectoderm for development past egg cylinder stage
• no morphological abnormalities in embryonic and extraembryonic ectoderm
• lack of regionalizationof the visceral endoderm
• axis formation defects in endoderm
• growth from E5.5 to E7.5 represents a 2.5 fold reduction compared to wild-type
• at E6.5 mutant embryos more compact (shorter) than wild-type
• at E7.5

growth/size/body
• growth from E5.5 to E7.5 represents a 2.5 fold reduction compared to wild-type
• at E6.5 mutant embryos more compact (shorter) than wild-type


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/05/2019
MGI 6.14
The Jackson Laboratory