Phenotypes Associated with This Genotype

Genotype
MGI:2674087

• Allelic Composition: P2ry12^tm1Pcon/P2ry12^tm1Pcon
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal platelet physiology ( J:84917 )

• platelet adhesion to vWF is impaired, while adhesion to fibrinogen appears normal and adhesion to collagen is slightly increased

• platelets activated either with TRAP or ADP bind less fibrinogen than wild-type

decreased platelet aggregation ( J:84917 )

• platelet activation is reduced in response to ADP or a PAR-4 activating peptide

decreased susceptibility to induced thrombosis ( J:84917 )

• though platelet counts were normal, a delay in thrombus formation was observed using an in vivo mesenteric artery injury model and only small, unstable thrombi form without reaching occlusive size

increased bleeding time ( J:84917 )

hematopoietic system

abnormal platelet physiology ( J:84917 )

• platelet adhesion to vWF is impaired, while adhesion to fibrinogen appears normal and adhesion to collagen is slightly increased

• platelets activated either with TRAP or ADP bind less fibrinogen than wild-type

decreased platelet aggregation ( J:84917 )

• platelet activation is reduced in response to ADP or a PAR-4 activating peptide

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
platelet-type bleeding disorder 8		DOID:0060692	OMIM:609821	J:84917