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Phenotypes Associated with This Genotype
Genotype
MGI:2674087
Allelic
Composition
P2ry12tm1Pcon/P2ry12tm1Pcon
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
P2ry12tm1Pcon mutation (0 available); any P2ry12 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• though platelet counts were normal a delay in thrombus formation was observed using an in vivo mesenteric artery injury model and only small, unstable thrombi form without reaching occlusive size
• platelet adhesion to vWF is impaired, while adhesion to fibrinogen appears normal and adhesion to collagen is slightly increased
• platelets activated either with TRAP or ADP bind less fibrinogen than wild-type
• platelet activation is reduced in response to ADP or a PAR-4 activating peptide

hematopoietic system
• platelet adhesion to vWF is impaired, while adhesion to fibrinogen appears normal and adhesion to collagen is slightly increased
• platelets activated either with TRAP or ADP bind less fibrinogen than wild-type
• platelet activation is reduced in response to ADP or a PAR-4 activating peptide

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
platelet-type bleeding disorder 8 DOID:0060692 OMIM:609821
J:84917


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory