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Phenotypes Associated with This Genotype
Genotype
MGI:2674082
Allelic
Composition		 H1f2tm2Ais/H1f2tm2Ais
H1f3tm2Ais/H1f3+
H1f4tm2Ais/H1f4tm2Ais
Genetic
Background		 involves: 129/Sv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H1f2tm2Ais mutation (0 available); any H1f2 mutation (17 available)
H1f3tm2Ais mutation (0 available); any H1f3 mutation (8 available)
H1f4tm2Ais mutation (0 available); any H1f4 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:83954 )
• very mild shortening of life span
prenatal lethality, incomplete penetrance ( J:83954 )
• homozygotes are under represented in litters at birth

growth/size/body
decreased body size ( J:83954 )
• mice are much smaller at birth and as adults

immune system
small thymus ( J:83954 )
• histologically normal however

reproductive system
reduced fertility ( J:83954 )
• both male and female mutants are fertile when crossed to wild-type mice but display reduced fertility when crossed to one another

hematopoietic system
small thymus ( J:83954 )
• histologically normal however

endocrine/exocrine glands
small thymus ( J:83954 )
• histologically normal however

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory