Phenotypes Associated with This Genotype

Genotype
MGI:2674072

• Allelic Composition: H1f2^tm2Ais/H1f2^tm2Ais; H1f3^tm2Ais/H1f3^tm2Ais; H1f4^tm2Ais/H1f4^tm2Ais
• Genetic Background: involves: 129/Sv * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:83954 )

• no triple homozygotes are born

• no triple homozygous embryos after E11.5

• only about 25% as many embryos at E10.5 as expected

embryonic lethality between implantation and somite formation, incomplete penetrance ( J:83954 )

• triple homozygotes are under represented by E7.5

cardiovascular system

absent vitelline blood vessels ( J:83954 )

• no visible blood or blood vessels at E10.5

enlarged pericardium ( J:83954 )

• at E9.5

embryo

abnormal rostral-caudal axis patterning ( J:83954 )

• arrested posterior development while anterior development remained normal at E9.5

rostral-caudal axis duplication ( J:83954 )

• partial or complete axis duplication in early somite stage embryos (n=2)

embryonic growth retardation ( J:83954 )

decreased embryo size ( J:83954 )

• embryos between E7.5 and E11.5 are reduced in size

• retarded development based on somite number

• E10.5 embryos with 16-18 somites as opposed to an expected 26-30 somites

abnormal neural tube morphology ( J:83954 )

• varied from mild to more severe (splayed anterior neural tube)

abnormal extraembryonic tissue morphology ( J:83954 )

absent vitelline blood vessels ( J:83954 )

• no visible blood or blood vessels at E10.5

abnormal visceral yolk sac morphology ( J:83954 )

pale yolk sac ( J:83954 )

failure of chorioallantoic fusion ( J:83954 )

• failed chorioallantoic fusion at E9.5

growth/size/body

embryonic growth retardation ( J:83954 )

decreased embryo size ( J:83954 )

• embryos between E7.5 and E11.5 are reduced in size

• retarded development based on somite number

• E10.5 embryos with 16-18 somites as opposed to an expected 26-30 somites

limbs/digits/tail

short tail ( J:83954 )

• at E9.5

nervous system

abnormal neural tube morphology ( J:83954 )

• varied from mild to more severe (splayed anterior neural tube)