Phenotypes Associated with This Genotype

Genotype
MGI:2673582

• Allelic Composition: Icosl^tm1Kplm/Icosl^tm1Kplm
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal spleen germinal center morphology ( J:84893 )

• impaired germinal center formation

abnormal humoral immune response ( J:84893 )

• impaired interaction between T and B cells

• while normal repsonses are mounted against both type I and type II T-cell-independent antigens, the response to T-cell-dependent antigen is attenuated and mutants fail to mount a secondary immune response to the same antigen

abnormal immune serum protein physiology ( J:84893 )

• reduced basal serum levels of heavy chain class-switched antibodies

• the levels could not be elevated with repeated immunizations

decreased IgA level ( J:84893 )

decreased IgG2a level ( J:84893 )

decreased IgG2b level ( J:84893 )

increased interferon-gamma secretion ( J:84893 )

• isolated CD4+ T cells of KLH/CFA-immunized mutants that were restimulated in vitro with KLH produce much more IFN-gamma than wild-type

decreased interleukin-10 secretion ( J:84893 )

• isolated CD4+ T cells of KLH/CFA-immunized mutants that were restimulated in vitro with KLH secrete very little IL-10 compared to wild-type

decreased interleukin-4 secretion ( J:84893 )

• isolated CD4+ T cells of KLH/CFA-immunized mutants that were restimulated in vitro with KLH secrete very little IL-4 compared to wild-type

hematopoietic system

abnormal spleen germinal center morphology ( J:84893 )

• impaired germinal center formation

decreased IgA level ( J:84893 )

decreased IgG2a level ( J:84893 )

decreased IgG2b level ( J:84893 )