Phenotypes Associated with This Genotype

Genotype
MGI:2673488

• Allelic Composition: H2ax^tm1Fwa/H2ax⁺; Trp53^tm1Brd/Trp53^tm1Brd
• Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:84879 )

• 50% mortality by 17 weeks of age

neoplasm

increased lymphoma incidence ( J:84879 )

• develop lymphomas very early

increased T cell derived lymphoma incidence ( J:84879 )

increased B cell derived lymphoma incidence ( J:84879 )

• B lineage lymphomas, including Igmu+/IgL- pre-B cell lymphoma and IgM- B lineage lymphoma

• often harboring translocations involving chromosomes 12 (Igh) and 15 (Myc)

increased sarcoma incidence ( J:84879 )

increased teratoma incidence ( J:84879 )

• develop teratomas very early

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:84879 )