Phenotypes Associated with This Genotype

Genotype
MGI:2673421

• Allelic Composition: Hoxb8^tm1.1Mrc/Hoxb8^tm1.1Mrc
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased grooming behavior ( J:73745 )

• spend almost twice as much time grooming compared to controls, initiate grooming more frequently, spend excessive time on body licking and biting which leads to hair loss, and excessively groom cagemates, however forelimb clasping, motor control and rearing are normal

abnormal sleep pattern ( J:73745 )

• spend on average one hour less time sleeping than controls

skeleton

skeleton phenotype ( J:73745 )

N • no defects in the formation of the first rib are detected

nervous system

nervous system phenotype ( J:73745 )

N • no defects either in formation or maintenance of the dorsal root ganglia

integument

abnormal coat appearance ( J:73745 )

• varied hair loss showing large bald patches on lateral and ventral body surfaces due to excessive grooming

abnormal skin condition ( J:73745 )

• self-inflicted skin lesions due to excessive grooming, with thickened epidermis in hairless patches of older mice, however observe no inflammation in the area and no defect in cutaneous sensation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
trichotillomania		DOID:0050587	OMIM:613229	J:73745