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Phenotypes Associated with This Genotype
Genotype
MGI:2673421
Allelic
Composition
Hoxb8tm1.1Mrc/Hoxb8tm1.1Mrc
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb8tm1.1Mrc mutation (0 available); any Hoxb8 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• spend almost twice as much time grooming compared to controls, initiate grooming more frequently, spend excessive time on body licking and biting which leads to hair loss, and excessively groom cagemates, however forelimb clasping, motor control and rearing are normal
• spend on average one hour less time sleeping than controls

skeleton
N
• no defects in the formation of the first rib are detected

nervous system
N
• no defects either in formation or maintenance of the dorsal root ganglia

integument
• varied hair loss showing large bald patches on lateral and ventral body surfaces due to excessive grooming
• self-inflicted skin lesions due to excessive grooming, with thickened epidermis in hairless patches of older mice, however observe no inflammation in the area and no defect in cutaneous sensation

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
trichotillomania DOID:0050587 OMIM:613229
J:73745


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory