Phenotypes Associated with This Genotype

Genotype
MGI:2673243

• Allelic Composition: Ctnnb1^tm4Wbm/Ctnnb1^tm4Wbm; Tg(Pou3f4-cre)32Cren/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal nervous system morphology ( J:83935 )

• proliferation of cells declined by E10

• 45% at E11 to 50% at E11.5

• E11 proliferation rate down 35%

• 4.8X increase in progenitor cell death and apoptosis

• higher proportion of differentiated neurons to proliferative cells

• number of neurons unchanged

abnormal brain morphology ( J:83935 )

decreased brain size ( J:83935 )

• changes similar to those seen in the spinal cord

• tissue mass of the midbrain was reduced

• progenitor domains in the midbrain and other areas of the brain reduced

• increased apoptosis

decreased spinal cord size ( J:83935 )

• ventricular zone absent at E12

• reduced area occupied by progenitor cells

• ventral progenitor are absent by E11.5

• absent dorsally by E12

• Larger area occupied by differentiated neurons(as determined immunohistochemically and gene markers)