Phenotypes Associated with This Genotype

Genotype
MGI:2673173

• Allelic Composition: Hoxb4^tm1Bay/Hoxb4^tm1Bay
• Genetic Background: 129S/SvEv-Hoxb4^tm1Bay

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:4612 )

• Background Sensitivity: on a co-isogenic background, 100% of homozygotes die within 1 day of birth; in contrast, on a mixed genetic background involving 129S7/SvEvBrd and C57BL/6J, 50% of homozygotes die perinatally while the remaining 50% survive to adulthood

skeleton

abnormal sternebra morphology ( J:4612 )

• all newborn homozygotes exhibit duplicated sternebrae as a result of a longitudinally split sternum

split sternum ( J:4612 )

• 100% of newborn homozygotes display a completely slit sternum

• a longitudinally split sternum is observed at all stages examined from E14.5 onward

abnormal cervical axis morphology ( J:4612 )

• only 1 of 3 newborn homozygotes show an extra ventral tubercle on the cervical axis (C2)

cervical vertebral transformation ( J:4612 )

• only 1 of 3 newborn homozygotes show a partial anterior homeotic transformation of the cervical axis (C2) to atlas (C1)