Phenotypes Associated with This Genotype

Genotype
MGI:2673162

• Allelic Composition: Ppp1r9b^tm1Jfe/Ppp1r9b^tm1Jfe
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

enhanced behavioral response to cocaine ( J:110264 )

• mice are more sensitive to the acute locomotor activating effects of cocaine and show enhanced reward responses to cocaine

decreased susceptibility to pharmacologically induced seizures ( J:77284 )

• injection of kaniate resulted in partial or no seizures in homozygous mice while wild-type mice exhibited severe systemic seizures

abnormal conditioned taste aversion behavior ( J:79257 )

• homozygous mice exhibited impaired associative learning ability compared to wild-type; mice can exhibit learning at higher doses of an aversive stimulus or with more salient flavor stimuli

growth/size/body

decreased body weight ( J:77284 )

• mutant animals weighed approximately 14% less than littermates

nervous system

decreased susceptibility to pharmacologically induced seizures ( J:77284 )

• injection of kaniate resulted in partial or no seizures in homozygous mice while wild-type mice exhibited severe systemic seizures

decreased brain size ( J:77284 )

abnormal hippocampus morphology ( J:77284 )

abnormal hippocampus layer morphology ( J:77284 )

• decrease in thickness of several layers was noted

small hippocampus ( J:77284 )

• reduced in size by approximately 39%

abnormal neuron morphology ( J:77284 )

• neurons from the caudatoputamen of P15 mutant mice exhibited a greater density of dendritic spines than littermates; this increase became undetectable in adult mice

abnormal neuron physiology ( J:110264 )

• alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate responses in striatal neuron are significantly attenuated and are unaffected by Dopamine D1 receptor agonist, SKF 81297

decreased susceptibility to neuronal excitotoxicity ( J:77284 )

• hippocampal neurons from homozygous mice exhibited resistance to apoptosis induced by kaniate or by glutamate

abnormal AMPA-mediated synaptic currents ( J:77284 )

• the amplitude of induced AMPA receptor currents declines much more slowly than in the wild-type

absent long-term depression ( J:110264 )

• high-frequency stimulation of corticostriatal terminals fails to produce long term depression bathing cells in a dopamine D2 like receptor agonist (quinpirole) restores corticostriatal LTP

reduced long-term depression ( J:77284 )

• shown in hippocampal slices derived from the in CA1 region

homeostasis/metabolism

decreased susceptibility to neuronal excitotoxicity ( J:77284 )

• hippocampal neurons from homozygous mice exhibited resistance to apoptosis induced by kaniate or by glutamate

cellular

decreased susceptibility to neuronal excitotoxicity ( J:77284 )

• hippocampal neurons from homozygous mice exhibited resistance to apoptosis induced by kaniate or by glutamate