Mouse Genome Informatics
hm
    Keratm1Cyl/Keratm1Cyl
Not Specified
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
vision/eye
• the cornea-iris angle of the anterior segment was 30-40% narrower
• corneal stroma was 40 % thinner than wild-type
• collagen fibrils were larger with circular profiles
• anterior fibril diameters were 30.7 nm as opposed to 26.6
• posterior fibril diameters were 32 nm as opposed to 26.9
• fibril packing was less regular

immune system
• the number of neutrophils in LPS-treated corneas is decreased compared to in similarly treated wild-type mice
• however, CXC chemokine production is normal
• following lethal irradiation and transplantation of EGFP+ cells, infiltration of bone marrow-derived inflammatory cells into LPS treated corneas is reduced compared to in similarly treated wild-type mice

hematopoietic system
• the number of neutrophils in LPS-treated corneas is decreased compared to in similarly treated wild-type mice
• however, CXC chemokine production is normal

Mouse Models of Human Disease
OMIM IDRef(s)
Cornea Plana 2; CNA2 217300 J:83873