Phenotypes Associated with This Genotype

Genotype
MGI:2672870

• Allelic Composition: Icosl^tm1Mak/Icosl^tm1Mak
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal class switch recombination ( J:84668 )

• B cell isotype switching was impaired

abnormal T-helper 2 cell differentiation ( J:84668 )

• impaired TH2 differentiation

abnormal spleen morphology ( J:84668 )

decreased spleen germinal center number ( J:84668 )

• the mean number of germinal centers is severely reduced

decreased spleen germinal center size ( J:84668 )

• the size of the germinal centers is severely reduced

decreased IgG1 level ( J:84668 )

• IgG1 is the only immunoglobulin to be significantly reduced in amount

immune system

immune system phenotype ( J:84668 )

N • T and B cell development was unaffected and the overall composition of T and B cells in the spleen was normal

abnormal T-helper 2 cell differentiation ( J:84668 )

• impaired TH2 differentiation

abnormal spleen morphology ( J:84668 )

decreased spleen germinal center number ( J:84668 )

• the mean number of germinal centers is severely reduced

decreased spleen germinal center size ( J:84668 )

• the size of the germinal centers is severely reduced

abnormal immune system physiology ( J:84668 )

• affinity maturation of IgG1 was impaired

• IgE response was reduced to sensitization with aerosolized antigen after repeated immunization

• interaction between T and B cells was impaired

abnormal class switch recombination ( J:84668 )

• B cell isotype switching was impaired

decreased IgG1 level ( J:84668 )

• IgG1 is the only immunoglobulin to be significantly reduced in amount

decreased inflammatory response ( J:84668 )

• inflammatory response was significantly reduced

• fewer T cells producing IL4 and IL-10

• IFN-gamma production unaffected