Phenotypes Associated with This Genotype

Genotype
MGI:2672797

• Allelic Composition: Cd81^tm1Tmiy/Cd81^tm1Tmiy
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased B cell proliferation ( J:41830 )

• reduced B cell proliferation after surface IgM crosslinking

• T-cell dependent B-cell activation partially reduced

increased B cell proliferation ( J:41830 )

• enhanced proliferation after stimulation with anti-CD4 Ab or LPS

abnormal T cell proliferation ( J:41830 )

• enhanced proliferation after stimulaiton with anti-CD3 Ab, concanavalin A (ConA), or in mixed lymphocyte reaction (MLR)

abnormal B cell differentiation ( J:41830 )

• reduced cell surface expression of CD19

• CD19 not down regulated

decreased B-1 B cell number ( J:41830 )

• reduction in peritoneal B1 cells

abnormal macrophage physiology ( J:83795 )

• homozygotes display enhanced formation of multinucleated giant cells after stimulation

immune system

decreased B cell proliferation ( J:41830 )

• reduced B cell proliferation after surface IgM crosslinking

• T-cell dependent B-cell activation partially reduced

increased B cell proliferation ( J:41830 )

• enhanced proliferation after stimulation with anti-CD4 Ab or LPS

abnormal T cell proliferation ( J:41830 )

• enhanced proliferation after stimulaiton with anti-CD3 Ab, concanavalin A (ConA), or in mixed lymphocyte reaction (MLR)

abnormal macrophage physiology ( J:83795 )

• homozygotes display enhanced formation of multinucleated giant cells after stimulation

abnormal immune system cell morphology ( J:41830 )

abnormal B cell differentiation ( J:41830 )

• reduced cell surface expression of CD19

• CD19 not down regulated

decreased B-1 B cell number ( J:41830 )

• reduction in peritoneal B1 cells

cellular

decreased B cell proliferation ( J:41830 )

• reduced B cell proliferation after surface IgM crosslinking

• T-cell dependent B-cell activation partially reduced

increased B cell proliferation ( J:41830 )

• enhanced proliferation after stimulation with anti-CD4 Ab or LPS

abnormal T cell proliferation ( J:41830 )

• enhanced proliferation after stimulaiton with anti-CD3 Ab, concanavalin A (ConA), or in mixed lymphocyte reaction (MLR)