Phenotypes Associated with This Genotype

Genotype
MGI:2671969

• Allelic Composition: Sag^tm1Jnc/Sag^tm1Jnc
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

vision/eye phenotype ( J:139694 )

N • mice exhibit normal cone electrophysiology

abnormal retina rod cell outer segment morphology ( J:43294 )

• the rod outer segment is disorganized and 25% shorter than in wild-type mice

• however, raising mice in darkness reduces the effect

abnormal rod electrophysiology ( J:43294 , J:120882 )

• rods exhibit an abnormal falling phase of the flash response compared to in wild-type mice (J:43294)

• recovery from flash response is prolonged in the final phase unlike wild type mice (J:43294)

• however, response to light adaptation is normal (J:43294)

• slow phase of the dim-flash response is 10-fold longer than in the Arrb1^tm1Jnc Rho^tm1Shda double homozygotes (J:120882)

• prolonged decay of slow-phase response is associated with increased meta-II decay (J:120882)

nervous system

abnormal retina rod cell outer segment morphology ( J:43294 )

• the rod outer segment is disorganized and 25% shorter than in wild-type mice

• however, raising mice in darkness reduces the effect