Phenotypes Associated with This Genotype

Genotype
MGI:2671953

• Allelic Composition: Lmo2^tm2(cre)Thr/Lmo2⁺; Kmt2a^tm1Thr/Kmt2a⁺; Mllt1^tm1Thr/Mllt1⁺
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:84518 )

• 100% of mutants either die or are sacrified due to ill health by 120 days of age

neoplasm

increased hemolymphoid system tumor incidence ( J:100794 )

• all mice develop hematological malignancies

• infiltration of malignant cells occurs in the liver, kidney, lungs and lymph nodes

increased leukemia incidence ( J:84518 , J:100794 )

• develop myeloid leukemias as early as 1.5 months of age (J:84518)

• leukemic cells invade the spleen and into peripheral organs such as liver and kidneys with perivascular deposits of tumor cells in liver and in between glomerili of kidney (J:84518)

• mice have myelo-proliferative-like myeloid leukemia (J:100794)

hematopoietic system

enlarged spleen ( J:84518 , J:100794 )

• splenomeglia is caused by a repopulation of the spleen with malignant cells (J:100794)

abnormal spleen red pulp morphology ( J:100794 )

• red and white pulp architecture is lost

abnormal spleen white pulp morphology ( J:100794 )

• red and white pulp architecture is lost

immune system

enlarged spleen ( J:84518 , J:100794 )

• splenomeglia is caused by a repopulation of the spleen with malignant cells (J:100794)

abnormal spleen red pulp morphology ( J:100794 )

• red and white pulp architecture is lost

abnormal spleen white pulp morphology ( J:100794 )

• red and white pulp architecture is lost

liver/biliary system

pale liver ( J:84518 )

renal/urinary system

pale kidney ( J:84518 )

growth/size/body

enlarged spleen ( J:84518 , J:100794 )

• splenomeglia is caused by a repopulation of the spleen with malignant cells (J:100794)