Phenotypes Associated with This Genotype

Genotype
MGI:2671930

• Allelic Composition: \Ilk^tm1Star/\Ilk^tm1Star; \Tg(Col2a1-cre)1Star/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

disproportionate dwarf ( J:84273 )

• newborn homozygotes were smaller than normal with the small size becoming more conspicuous with age

• forelimbs and hind limbs were shortened but not deformed

skeleton

abnormal skeleton development ( J:84273 )

chondrodystrophy ( J:84273 )

• moderate chondrodysplasia

• growth plate most affected in the proliferating zone

• Cyclin D1 expression reduced in the proliferating zone

• poor columnar organization

• chondrocytes more rounded

• chondrocyte differentiation unaffected

• apoptosis normal