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Phenotypes Associated with This Genotype
Genotype
MGI:2670915
Allelic
Composition
Rgntm1Aish/Rgntm1Aish
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rgntm1Aish mutation (0 available); any Rgn mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system
• hepatocytes exposed to RNF-alpha and actinomycin D showed a 40% higher level of apoptosis than did cells from wild-type
• caspase-8 activity was doubled
• animals became more susceptible to apoptosis after receiving non-lethal doses of anti-FAS antibody

cellular
• hepatocytes exposed to RNF-alpha and actinomycin D showed a 40% higher level of apoptosis than did cells from wild-type
• caspase-8 activity was doubled
• animals became more susceptible to apoptosis after receiving non-lethal doses of anti-FAS antibody

homeostasis/metabolism
• total vitamin C level in lenses is reduced at 16 weeks of age

vision/eye
• mice fed a vitamin C-deficient diet and exposed to UVR-B exhibit a greater lens opacity than in controls; location indicates anterior sub-capsular cataract


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory