Phenotypes Associated with This Genotype

Genotype
MGI:2670915

• Allelic Composition: Rgn^tm1Aish/Rgn^tm1Aish
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

increased hepatocyte apoptosis ( J:79342 )

♀ • hepatocytes exposed to RNF-alpha and actinomycin D showed a 40% higher level of apoptosis than did cells from wild-type

♀ • caspase-8 activity was doubled

♀ • animals became more susceptible to apoptosis after receiving non-lethal doses of anti-FAS antibody

cellular

increased hepatocyte apoptosis ( J:79342 )

♀ • hepatocytes exposed to RNF-alpha and actinomycin D showed a 40% higher level of apoptosis than did cells from wild-type

♀ • caspase-8 activity was doubled

♀ • animals became more susceptible to apoptosis after receiving non-lethal doses of anti-FAS antibody

homeostasis/metabolism

abnormal vitamin C level ( J:191530 )

♀ • total vitamin C level in lenses is reduced at 16 weeks of age

vision/eye

anterior subcapsular cataract ( J:191530 )

♀ • mice fed a vitamin C-deficient diet and exposed to UVR-B exhibit a greater lens opacity than in controls; location indicates anterior sub-capsular cataract