Phenotypes Associated with This Genotype

Genotype
MGI:2670564

• Allelic Composition: Prdx1^tm1Rave/Prdx1⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hemolytic anemia ( J:84677 )

• aging heterozygotes exhibit an increased frequency of hemolytic anemia starting at ~12 months of age

• hemolytic anemia is caused by intra-erythrocytic oxidative damage and shows clinicopathological features similar to those observed in homozygous mutant mice, but is not fatal

neoplasm

abnormal tumor morphology ( J:84677 )

• malignancies are frequently associated with loss of Prdx1 expression in heterozygotes, which suggests that this protein functions as a tumour suppressor

increased lymphoma incidence ( J:84677 )

• 21% of heterozygotes develop lymphomas

increased histiocytic sarcoma incidence ( J:84677 )

• 37% of heterozygotes develop histiocytic sarcomas

increased malignant tumor incidence ( J:84677 )

• heterozygotes display an increased frequency of malignant tumors starting at ~12 months of age; however, malignancy is not associated with a reduction in overall survival

• 38% of tumour-bearing heterozygotes exhibited two independent malignancies

increased mammary adenocarcinoma incidence ( J:84677 )

• 12% of heterozygotes develop breast adenocarcinomas

increased hepatocellular carcinoma incidence ( J:84677 )

• 13% of heterozygotes develop hepatocellular carcinomas

increased lung adenocarcinoma incidence ( J:84677 )

• 6% of heterozygotes develop lung adenocarcinomas

increased fibrosarcoma incidence ( J:84677 )

• 25% of heterozygotes develop fibrosarcomas

increased hemangiosarcoma incidence ( J:84677 )

• 19% of heterozygotes develop hemangiosarcomas

increased osteosarcoma incidence ( J:84677 )

• 6% of heterozygotes develop osteosarcomas

cellular

increased cellular sensitivity to oxidative stress ( J:84677 )

• erythrocytes from anemic heterozygotes display an increase in baseline ROS, not observed in healthy (non-anemic) heterozygotes or wild-type mice

increased cellular sensitivity to hydrogen peroxide induced cell death ( J:84677 )

• erythrocytes from anemic heterozygotes display an increase in ROS generated in response to hydrogen peroxide challenge

integument

increased mammary adenocarcinoma incidence ( J:84677 )

• 12% of heterozygotes develop breast adenocarcinomas

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:84677 )

• 12% of heterozygotes develop breast adenocarcinomas

respiratory system

increased lung adenocarcinoma incidence ( J:84677 )

• 6% of heterozygotes develop lung adenocarcinomas

liver/biliary system

increased hepatocellular carcinoma incidence ( J:84677 )

• 13% of heterozygotes develop hepatocellular carcinomas

skeleton

increased osteosarcoma incidence ( J:84677 )

• 6% of heterozygotes develop osteosarcomas

homeostasis/metabolism

increased cellular sensitivity to oxidative stress ( J:84677 )

• erythrocytes from anemic heterozygotes display an increase in baseline ROS, not observed in healthy (non-anemic) heterozygotes or wild-type mice

increased cellular sensitivity to hydrogen peroxide induced cell death ( J:84677 )

• erythrocytes from anemic heterozygotes display an increase in ROS generated in response to hydrogen peroxide challenge