Mouse Genome Informatics
hm
    Ldlrap1tm1Her/Ldlrap1tm1Her
involves: 129S6/SvEvTac
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
homeostasis/metabolism
• LDL clearance is slowed
• on a chow diet, plasma LDL levels were higher than those in wild-type mice but lower than those in Ldlrtm1Her homozygous mutant mice
• little LDL accumulation on a normal diet
• on high cholesterol diets most plasma cholesterol is LDL
• plasma cholesterol is only mildly elevated (83mg/dl) on a normal diet
• plasma triglycerides increase more on a "wetern" diet than in Ldlrtm1Her homozygous mutant mice

Mouse Models of Human Disease
OMIM IDRef(s)
Hypercholesterolemia, Autosomal Recessive; ARH 603813 J:84694