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Phenotypes Associated with This Genotype
Genotype
MGI:2670516
Allelic
Composition
Ldlrap1tm1Her/Ldlrap1tm1Her
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrap1tm1Her mutation (1 available); any Ldlrap1 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• LDL clearance is slowed
• on a chow diet, plasma LDL levels were higher than those in wild-type mice but lower than those in Ldlrtm1Her homozygous mutant mice
• little LDL accumulation on a normal diet
• on high cholesterol diets most plasma cholesterol is LDL
• plasma cholesterol is only mildly elevated (83mg/dl) on a normal diet
• plasma triglycerides increase more on a "wetern" diet than in Ldlrtm1Her homozygous mutant mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Hypercholesterolemia, Autosomal Recessive; ARH 603813 J:84694


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory