Analysis Tools
hematopoietic system
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• treatment of thymocytes and peripheral T cells with anti-CD3 to mimic high affinity TCR interaction results in less apoptosis than observed in heterozygous controls
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• at 2-5 weeks of age, thymi are generally ~10% larger than in heterozygotes; by 29 to 32 weeks of age, difference has become ~30%
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• small but significant increase in total number of thymocytes is seen compared to heterozygous controls
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• induction of DP thymocytes by anti-CD3, suggesting that negative selection is impaired by deficiency
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immune system
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• treatment of thymocytes and peripheral T cells with anti-CD3 to mimic high affinity TCR interaction results in less apoptosis than observed in heterozygous controls
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• at 2-5 weeks of age, thymi are generally ~10% larger than in heterozygotes; by 29 to 32 weeks of age, difference has become ~30%
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• small but significant increase in total number of thymocytes is seen compared to heterozygous controls
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• induction of DP thymocytes by anti-CD3, suggesting that negative selection is impaired by deficiency
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cellular
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• treatment of thymocytes and peripheral T cells with anti-CD3 to mimic high affinity TCR interaction results in less apoptosis than observed in heterozygous controls
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endocrine/exocrine glands
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• at 2-5 weeks of age, thymi are generally ~10% larger than in heterozygotes; by 29 to 32 weeks of age, difference has become ~30%
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• small but significant increase in total number of thymocytes is seen compared to heterozygous controls
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