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Phenotypes Associated with This Genotype
Genotype
MGI:2670271
Allelic
Composition
Ro60tm1Woln/Ro60tm1Woln
Genetic
Background
involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ro60tm1Woln mutation (0 available); any Ro60 mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Glomerulonephritis in Ro60tm1Woln/Ro60tm1Woln mice

mortality/aging
• Background Sensitivity: approximately 28% mortality within 12 months of age, mixed genetic background involving 129S1/Sv and C57BL/6 but not when backcrossed to C57BL/6 background for 3 generations

renal/urinary system
• membranoproliferative glomerulonephritis observed in mice on mixed genetic background involving 129S1/Sv and C57BL/6 and in mice that had been backcrossed to C57BL/6 background for 3 generations

immune system
• 29-fold increase in unimmunized 8-week old mutants
• 1.5-fold increase in in unimmunized 8-week old mutants
• anti-chromatin and anti-ribosome antibodies were detected on mixed genetic background involving 129S1/Sv and C57BL/6 and in mice that had been backcrossed to C57BL/6 background for 3 generations
• membranoproliferative glomerulonephritis observed in mice on mixed genetic background involving 129S1/Sv and C57BL/6 and in mice that had been backcrossed to C57BL/6 background for 3 generations

integument
N
• Background Sensitivity: keratinocytes from mice on a mixed 129S1/Sv and C57BL/6 background show similiar sensitivity to UVB exposure as wild-type mice compared to mutants backcrossed to C57BL/6 for 6 generations which show increased apoptosis

hematopoietic system
• 29-fold increase in unimmunized 8-week old mutants
• 1.5-fold increase in in unimmunized 8-week old mutants


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory