Phenotypes Associated with This Genotype

Genotype
MGI:2669615

• Allelic Composition: Pfn1^tm1Wit/Pfn1⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:77643 )

• in some genetic backgrounds, loss of some heterozygous embryos was noted in the perinatal period; surviving mice were phenotypically identical to wild-type littermates

prenatal lethality, incomplete penetrance ( J:77643 )

• a partial loss of heterozygous embryos occurred at the two to four cell stage when the mother was heterozygous, suggesting a maternal effect due to decreased levels of profilin I in oocytes