Analysis Tools
mortality/aging
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• die around E10-10.5
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growth/size/body
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• appears enlarged at E9
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• exhibit signs of growth retardation at E9.5 featured by a smaller head, underdeveloped nasal processes, and branchial arches
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microcephaly
(
J:58502
)
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• small head at E9.5
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embryo
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• yolk sacs at E9-9.5 show an abnormal vascular plexus
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• vitelline vessels are completely absent at E9.5 and are replaced by enlarged and leaky channels that release their content into the yolk sac cavity resulting in hemorrhage
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• exhibit underdeveloped branchial arches at E9.5
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• exhibit signs of growth retardation at E9.5 featured by a smaller head, underdeveloped nasal processes, and branchial arches
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• E10-10.5 embryos exhibit extensive tissue necrosis
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• blood islands at E9-9.5 are dilated and fused to generate abnormal and irregular channels
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cardiovascular system
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• collapsed vasculature
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• yolk sacs at E9-9.5 show an abnormal vascular plexus
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• vitelline vessels are completely absent at E9.5 and are replaced by enlarged and leaky channels that release their content into the yolk sac cavity resulting in hemorrhage
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• no mesenchymal cells are detected in E9 hearts, indicating that endocardial-mesenchymal transformation does not occur
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• the endocardium remains rudimentary at E9 in the primitive ventricle, whose lumen failed to close in the atrioventricular area
• some E9 embryos have an abnormally dilated endocardium in the common atrial chamber and the bulbus cordis
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• appears enlarged at E9
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• seen at E9.5
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• seen by E9; show blood accumulating in the peritoneal cavity, indicating that embryonic vessels are fragile and susceptible to rupture
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• at E10.5, heart is arrested and no longer beating and exhibits extensive necrosis
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homeostasis/metabolism
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• seen at E9.5
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craniofacial
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• exhibit underdeveloped nasal processes at E9.5
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• exhibit underdeveloped branchial arches at E9.5
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