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Phenotypes Associated with This Genotype
Genotype
MGI:2668968
Allelic
Composition
Foxj1tm1Bph/Foxj1tm1Bph
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxj1tm1Bph mutation (0 available); any Foxj1 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most homozygotes die during the first 4 days of life (J:50025)
• only 2.6% of homozygotes are obtained at 2-3 weeks of age (J:50025)
• rare male and female homozygotes survive beyond 12 weeks of age (J:50025)
• most homozygotes die during the first 4 days of life (J:50025)
• only 2.6% of homozygotes are obtained at 2-3 weeks of age (J:50025)
• rare male and female homozygotes survive beyond 12 weeks of age (J:50025)
• a significant portion of homozygotes die between E16.5 and E18.5 (J:50025)
• a significant portion of homozygotes die between E16.5 and E18.5 (J:50025)

growth/size/body
• newborn homozygotes are smaller in size than wild-type or heterozygous littermates (J:50025)
• newborn homozygotes are smaller in size than wild-type or heterozygous littermates (J:50025)
• moribund homozygotes exhibit a wasted appearance (J:50025)
• however, no respiratory distress is observed (J:50025)
• moribund homozygotes exhibit a wasted appearance (J:50025)
• however, no respiratory distress is observed (J:50025)
• rare postnatal survivors remain healthy but appear smaller than wild-type or heterozygous littermates (J:50025)
• rare postnatal survivors remain healthy but appear smaller than wild-type or heterozygous littermates (J:50025)
• newborn homozygotes exhibit poor postnatal weight gain (J:50025)
• newborn homozygotes exhibit poor postnatal weight gain (J:50025)
• by E16.5, homozygotes weigh significant less than wild-type controls (J:50025)
• by E16.5, homozygotes weigh significant less than wild-type controls (J:50025)
• at birth, a portion of homozygotes display heterotaxy with either reversal of the abdominal viscera and normal heart position or dextrocardia with normal positioning of the abdominal viscera (J:50025)
• at birth, a portion of homozygotes display heterotaxy with either reversal of the abdominal viscera and normal heart position or dextrocardia with normal positioning of the abdominal viscera (J:50025)
• at birth, 48.1% of homozygotes show reversal of the abdominal viscera and dextrocardia consistent with random determination of left-right asymmetry (J:50025)
• however, no asplenia or polysplenia is observed (J:50025)
• at birth, 48.1% of homozygotes show reversal of the abdominal viscera and dextrocardia consistent with random determination of left-right asymmetry (J:50025)
• however, no asplenia or polysplenia is observed (J:50025)

nervous system
• homozygotes exhibit complete absence of cilia in the chorid plexus (J:50025)
• homozygotes exhibit complete absence of cilia in the chorid plexus (J:50025)
• at >1 wk of age, 3 of 6 homozygotes exhibit hydrocephalus, with one of them dying at 4 weeks (J:50025)
• at >1 wk of age, 3 of 6 homozygotes exhibit hydrocephalus, with one of them dying at 4 weeks (J:50025)
• homozygotes exhibit complete absence of cilia in the chorid plexus (J:50025)
• homozygotes exhibit complete absence of cilia in the chorid plexus (J:50025)

embryogenesis
• at birth, 48.1% of homozygotes show reversal of the abdominal viscera and dextrocardia consistent with random determination of left-right asymmetry (J:50025)
• at birth, 48.1% of homozygotes show reversal of the abdominal viscera and dextrocardia consistent with random determination of left-right asymmetry (J:50025)

behavior/neurological
• moribund homozygotes are less active than wild-type mice (J:50025)
• moribund homozygotes are less active than wild-type mice (J:50025)

reproductive system
• homozygotes exhibit complete absence of cilia in the oviduct (J:50025)
• homozygotes exhibit complete absence of cilia in the oviduct (J:50025)
• mutant sperm lack flagella (J:50025)
• mutant sperm lack flagella (J:50025)
• rare postnatal male and female survivors fail to reproduce (J:50025)
• rare postnatal male and female survivors fail to reproduce (J:50025)

respiratory system
• homozygotes exhibit complete absence of cilia in the proximal respiratory epithelium (J:50025)
• homozygotes exhibit complete absence of cilia in the proximal respiratory epithelium (J:50025)

cardiovascular system
• at birth, 48.1% of homozygotes show dextrcardia associated with reversal of the abdominal viscera (J:50025)
• at birth, 48.1% of homozygotes show dextrcardia associated with reversal of the abdominal viscera (J:50025)

cellular
• homozygotes exhibit complete absence of cilia in the chorid plexus (J:50025)
• homozygotes exhibit complete absence of cilia in the chorid plexus (J:50025)
• homozygotes exhibit complete absence of cilia in the oviduct (J:50025)
• homozygotes exhibit complete absence of cilia in the oviduct (J:50025)
• homozygotes exhibit complete absence of cilia in the proximal respiratory epithelium (J:50025)
• homozygotes exhibit complete absence of cilia in the proximal respiratory epithelium (J:50025)
• mutant sperm lack flagella (J:50025)
• mutant sperm lack flagella (J:50025)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory