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Phenotypes Associated with This Genotype
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arg1tm1Rki mutation (1 available); any Arg1 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
• die at postnatal day 10-14

• total kidney arginase activity levels normal; ARG2 levels are thought to be induced two-fold in these mice
• elevated plasma arginine levels: four fold greater than the level of wild-type
• reduced plasma proline levels: one third of the level of wild-type
• reduced plasma ornithine levels: one half of the level of wild-type
• elevated plasma glutamic acid, citrulline and histidine levels: about 1.5 fold greater than the wild-type level
• reduced plasma valine, isoleucine and leucine levels: 0.4 to 0.5 of the level of wild-type
• plasma ammonia levels are increased 10 fold in mice exhibiting metabolic crisis

liver/biliary system
• nuclei and cytoplasm enlarged two to three fold in most cells; cytoplasmic inclusions also noted as well as other abnormalities; abnormal nuclei

nervous system
• normal brain morphology; no astrocyte defects noted

Mouse Models of Human Disease
OMIM ID Ref(s)
Argininemia 207800 J:83263

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.01
The Jackson Laboratory