Phenotypes Associated with This Genotype

Genotype
MGI:2668732

• Allelic Composition: Npm2^tm1Zuk/Npm2^tm1Zuk
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal oocyte morphology ( J:83658 )

♀ • DNA is diffuse with no condensations around the nucleolus

reduced female fertility ( J:83658 )

♀ • homozygous females are subfertile or infertile

♀ • about 21% of females fail to become pregnant and litter sizes are very small

decreased litter size ( J:83658 )

• litter sizes are very small, averaging less than 3 pups

embryo

abnormal embryonic tissue morphology ( J:83658 )

• abnormal embryogenesis

• egg maturation and fertilization is normal but cleavage to the two cell stage is reduced

• normal nucleoli are absent in nuclei of one cell embryos

cellular

abnormal oocyte morphology ( J:83658 )

♀ • DNA is diffuse with no condensations around the nucleolus