Phenotypes Associated with This Genotype

Genotype
MGI:2668564

• Allelic Composition: Gli3^TgBR/Gli3^TgBR
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality ( J:77245 )

craniofacial

abnormal craniofacial morphology ( J:77245 )

• craniofacial malformation

limbs/digits/tail

abnormal limb morphology ( J:77245 )

• abnormal limb orientation

polydactyly ( J:77245 )

• severe, with greater number of extra digits than heterozygotes

respiratory system

respiratory distress ( J:77245 )

• at birth

skeleton

abnormal skeleton morphology ( J:77245 )

• multiple skeletal malformations

nervous system

exencephaly ( J:77245 )

• occasional

absent optic nerve ( J:77245 )

• no optic nerve is detected by DiI forward filling of the retina

growth/size/body

herniated abdominal wall ( J:77245 )

• occasional extrusion of abdominal contents

vision/eye

absent optic nerve ( J:77245 )

• no optic nerve is detected by DiI forward filling of the retina

microphthalmia ( J:77245 )

• small or absent eyes

anophthalmia ( J:77245 )

• small or absent eyes