Phenotypes Associated with This Genotype

Genotype
MGI:2668538

• Allelic Composition: Hoxd4^tm1Bhr/Hoxd4^tm1Bhr; Rarg^tm1Ipc/Rarg^tm1Ipc
• Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body size ( J:58620 )

• considerably reduced

skeleton

abnormal basioccipital bone morphology ( J:58620 )

• malformed basioccipital bones in 1/3 of double homozygotes

abnormal cervical vertebrae morphology ( J:58620 )

• ectopic anterior arch on C3 in 83% of homozygotes

fusion of atlas and occipital bones ( J:58620 )

• basioccipital bone sometimes fuses to anterior arch of C1

reproductive system

male infertility ( J:58620 )

♂ • homozygous males are infertile but homozygous females are fertile

craniofacial

abnormal basioccipital bone morphology ( J:58620 )

• malformed basioccipital bones in 1/3 of double homozygotes

fusion of atlas and occipital bones ( J:58620 )

• basioccipital bone sometimes fuses to anterior arch of C1