Mouse Genome Informatics
ht
    Grb10Gt(Betageo)1Ward/Grb10+
involves: C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• approximately 12% of mice with a maternally inherited allele die shortly after birth

cellular
• only heterozygotes inheriting the allele from the mother display a phenotype

embryogenesis
• the size of the placenta is increased ~30% relative to wild-type

growth/size/body
• neonates are ~30% larger than wild-type
• embryonic overgrowth resulting in neonates that are ~30% larger than wild-type

liver/biliary system
• disproportionate overgrowth of the liver

homeostasis/metabolism
• hepatocytes have a very high glycogen content

respiratory system
• mice that die shortly after birth exhibit blood-filled alveoli
• mice that die shortly after birth exhibit a blood-filled trachea

Mouse Models of Human Disease
OMIM IDRef(s)
NOT Silver-Russell Syndrome; SRS 180860 J:84425