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Phenotypes Associated with This Genotype
Genotype
MGI:2668444
Allelic
Composition
Grb10Gt(Betageo)1Ward/Grb10+
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb10Gt(Betageo)1Ward mutation (0 available); any Grb10 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• approximately 12% of mice with a maternally inherited allele die shortly after birth

cellular
• only heterozygotes inheriting the allele from the mother display a phenotype

embryo
• the size of the placenta is increased ~30% relative to wild-type

growth/size/body
• neonates are ~30% larger than wild-type
• embryonic overgrowth resulting in neonates that are ~30% larger than wild-type

liver/biliary system
• hepatocytes have a very high glycogen content
• disproportionate overgrowth of the liver

homeostasis/metabolism
• hepatocytes have a very high glycogen content

respiratory system
• mice that die shortly after birth exhibit blood-filled alveoli
• mice that die shortly after birth exhibit a blood-filled trachea

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Silver-Russell Syndrome; SRS 180860 J:84425


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory