Analysis Tools
cellular
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• oocytes were observed to be enlarged and misshapen, first evident at 8 days of age
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mortality/aging
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• mutants with dermatitis survive ~90-95 weeks, while those that remain dermatitis-free survive ~110 weeks compared to heterozygotes or wild-type which can survive past 140 weeks
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• females were sterile by 15 weeks of age
(J:84269)
• female develop premature sterility due to global activation of primordial follicles soon after birth
(J:118179)
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neoplasm
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• female mice show shorter latency and increased growth of pituitary prolactinomas (7/16 vs 1/10 wild-type)
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• females show an increased incidence of ovarian neoplasms (4/16 compared to 0/10 wild-type)
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• after carcinogen (DMBA) treatment, homozygotes and heterozygotes show increased incidence of angiosarcomas compared to wild-type
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• 19/20 dermatitis-free mice develop tumors more rapidly (starting at ~25) and show a more rapid onset of tumors compared to mice developing dermatitis (tumors develop at ~90-95 weeks)
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growth/size/body
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• enlarged ovaries evident by 8 to 14 days of age
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nervous system
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• female mice show shorter latency and increased growth of pituitary prolactinomas (7/16 vs 1/10 wild-type)
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reproductive system
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• oocytes were observed to be enlarged and misshapen, first evident at 8 days of age
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• increased atresia by 8.5 weeks of age
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• increased activation resulting in the progression of increased numbers of follicles to more advanced stages of follicular development
• increased atresia by 8.5 weeks of age
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• enlarged ovaries evident by 8 to 14 days of age
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• females show an increased incidence of ovarian neoplasms (4/16 compared to 0/10 wild-type)
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• females were sterile by 15 weeks of age
(J:84269)
• female develop premature sterility due to global activation of primordial follicles soon after birth
(J:118179)
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• females cycled sporadically from 6 to 15 weeks but became acyclic
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• females became acyclic after 15 weeks of age
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• age dependent decline in female reproductive ability
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immune system
dermatitis
(
J:118179
)
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• mice develop dermatitis between 10-24 months of age; 15/35 mice had to be euthanized due to progressive skin ulcerations
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hematopoietic system
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• mice develop mild hemolytic anemia
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homeostasis/metabolism
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• decreased rate of glucose uptake following fast
(J:84269)
• modest glucose intolerance is observed
(J:118179)
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endocrine/exocrine glands
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• female mice show shorter latency and increased growth of pituitary prolactinomas (7/16 vs 1/10 wild-type)
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• increased atresia by 8.5 weeks of age
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• increased activation resulting in the progression of increased numbers of follicles to more advanced stages of follicular development
• increased atresia by 8.5 weeks of age
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• enlarged ovaries evident by 8 to 14 days of age
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• females show an increased incidence of ovarian neoplasms (4/16 compared to 0/10 wild-type)
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integument
dermatitis
(
J:118179
)
|
• mice develop dermatitis between 10-24 months of age; 15/35 mice had to be euthanized due to progressive skin ulcerations
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