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Phenotypes Associated with This Genotype
Genotype
MGI:2668335
Allelic
Composition
Foxo3tm1.1Rdp/Foxo3tm1.1Rdp
Genetic
Background
involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo3tm1.1Rdp mutation (1 available); any Foxo3 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• oocytes were observed to be enlarged and misshapen, first evident at 8 days of age

nervous system
• female mice show shorter latency and increased growth of pituitary prolactinomas (7/16 vs 1/10 wild-type)

mortality/aging
• mutants with dermatitis survive ~90-95 weeks, while those that remain dermatitis-free survive ~110 weeks compared to heterozygotes or wild-type which can survive past 140 weeks
• females were sterile by 15 weeks of age (J:84269)
• female develop premature sterility due to global activation of primordial follicles soon after birth (J:118179)

neoplasm
• females show an increased incidence of ovarian neoplasms (4/16 compared to 0/10 wild-type)
• female mice show shorter latency and increased growth of pituitary prolactinomas (7/16 vs 1/10 wild-type)
• after carcinogen (DMBA) treatment, homozygotes and heterozygotes show increased incidence of angiosarcomas compared to wild-type
• 19/20 dermatitis-free mice develop tumors more rapidly (starting at ~25) and show a more rapid onset of tumors compared to mice developing dermatitis (tumors develop at ~90-95 weeks)

reproductive system
• oocytes were observed to be enlarged and misshapen, first evident at 8 days of age
• increased activation resulting in the progression of increased numbers of follicles to more advanced stages of follicular development
• increased atresia by 8.5 weeks of age
• enlarged ovaries evident by 8 to 14 days of age
• females show an increased incidence of ovarian neoplasms (4/16 compared to 0/10 wild-type)
• females were sterile by 15 weeks of age (J:84269)
• female develop premature sterility due to global activation of primordial follicles soon after birth (J:118179)
• females cycled sporadically from 6 to 15 weeks but became acyclic
• females became acyclic after 15 weeks of age
• age dependent decline in female reproductive ability

immune system
• mice develop dermatitis between 10-24 months of age; 15/35 mice had to be euthanized due to progressive skin ulcerations

hematopoietic system
• mild compensated anemia
• mice develop mild hemolytic anemia

homeostasis/metabolism
• decreased rate of glucose uptake following fast (J:84269)
• modest glucose intolerance is observed (J:118179)

endocrine/exocrine glands
• increased activation resulting in the progression of increased numbers of follicles to more advanced stages of follicular development
• increased atresia by 8.5 weeks of age
• enlarged ovaries evident by 8 to 14 days of age
• females show an increased incidence of ovarian neoplasms (4/16 compared to 0/10 wild-type)
• female mice show shorter latency and increased growth of pituitary prolactinomas (7/16 vs 1/10 wild-type)

integument
• mice develop dermatitis between 10-24 months of age; 15/35 mice had to be euthanized due to progressive skin ulcerations


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory