Phenotypes Associated with This Genotype

Genotype
MGI:2667523

• Allelic Composition: Spen^tm1Hon/Spen^tm1Hon
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:82332 )

• death around E14.5

cardiovascular system

abnormal heart development ( J:82332 )

• defects in the formation of the cardiac septum and muscle

endocrine/exocrine glands

abnormal pancreas development ( J:82332 )

• perturbed differentiation of exocrine and endocrine cells

hematopoietic system

abnormal B cell differentiation ( J:82332 )

• increased differentiation of splenic B cells into marginal zone B cells; suppressed differentiation into follicular B cells in vitro

immune system

abnormal B cell differentiation ( J:82332 )

• increased differentiation of splenic B cells into marginal zone B cells; suppressed differentiation into follicular B cells in vitro

liver/biliary system

small liver ( J:82332 )

• ypoplastic liver

• 75% reduction in the number of fetal liver cells relative to wild-type

liver hypoplasia ( J:82332 )

• greater than 75% reduction in the number of fetal liver cells relative to wild-type

integument

translucent skin ( J:82332 )

• embryonic skin was transparent, loose, and overlaid a large amount of subcutaneous exudate