Phenotypes Associated with This Genotype

Genotype
MGI:2665553

• Allelic Composition: Rara^tm1Ipc/Rara^tm1Ipc
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Degenerative lesions in testes of 4 to 5 month old Rara^tm1Ipc/Rara^tm1Ipc mice

mortality/aging

premature death ( J:13574 )

• 3% survived to 1 to 2 months of age

neonatal lethality, incomplete penetrance ( J:13574 )

• progressive decline in numbers

• 60% were cannibalized within the first day of birth

skeleton

abnormal skeleton morphology ( J:21009 )

• in 4 of 21 mice

abnormal alisphenoid bone morphology ( J:42773 )

• low penentrance of a unilateral pterygoquadrate element (a cartilaginous or osseous extension fusing the incus to the alisphenoid bone)

abnormal hyoid bone morphology ( J:42773 )

• low penetrance of fusion between the greater horns of thyroid cartilage and the hyoid bone

abnormal incus morphology ( J:42773 )

• low penentrance of a unilateral pterygoquadrate element (a cartilaginous or osseous extension fusing the incus to the alisphenoid bone)

abnormal cricoid cartilage morphology ( J:42773 )

• 9 of 14 homozygotes show ventral extension of the cricoid cartilage

abnormal thyroid cartilage morphology ( J:42773 )

• low penetrance of fusion between the greater horns of thyroid cartilage and the hyoid bone

abnormal cervical vertebrae morphology ( J:21009 )

• dyssymphysis of cervical neural arches in 3 of 12 mice

abnormal cervical axis morphology ( J:21009 )

• in 3 of 21 mice

cervical vertebral fusion ( J:21009 )

• fusion of neural arches in 1 of 21 mice

cervical vertebral transformation ( J:21009 )

• C2 to C1 anterior transformation in 1 of 21 mice

endocrine/exocrine glands

abnormal testis morphology ( J:13574 )

♂ • degeneration of the germinal epithelium

seminiferous tubule degeneration ( J:13574 )

♂

growth/size/body

postnatal growth retardation ( J:13574 )

• slower growth rate after 1 to weeks of age

limbs/digits/tail

interdigital webbing ( J:13574 )

reproductive system

abnormal testis morphology ( J:13574 )

♂ • degeneration of the germinal epithelium

seminiferous tubule degeneration ( J:13574 )

♂

abnormal spermatogenesis ( J:13574 )

♂

oligozoospermia ( J:13574 )

♂ • reduced presence of spermatozoa in the epididymis

male infertility ( J:13574 )

♂ • males that survived past 2 months of age were incapable of siring offspring

craniofacial

abnormal alisphenoid bone morphology ( J:42773 )

• low penentrance of a unilateral pterygoquadrate element (a cartilaginous or osseous extension fusing the incus to the alisphenoid bone)

abnormal hyoid bone morphology ( J:42773 )

• low penetrance of fusion between the greater horns of thyroid cartilage and the hyoid bone

abnormal incus morphology ( J:42773 )

• low penentrance of a unilateral pterygoquadrate element (a cartilaginous or osseous extension fusing the incus to the alisphenoid bone)

hearing/vestibular/ear

abnormal incus morphology ( J:42773 )

• low penentrance of a unilateral pterygoquadrate element (a cartilaginous or osseous extension fusing the incus to the alisphenoid bone)

respiratory system

abnormal cricoid cartilage morphology ( J:42773 )

• 9 of 14 homozygotes show ventral extension of the cricoid cartilage

abnormal thyroid cartilage morphology ( J:42773 )

• low penetrance of fusion between the greater horns of thyroid cartilage and the hyoid bone

cellular

oligozoospermia ( J:13574 )

♂ • reduced presence of spermatozoa in the epididymis