Phenotypes for Cd74 H2-DMa MGI:2665538 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	H2-DMa^tm1Luc/H2-DMa^tm1Luc Cd74^tm1Doi/Cd74^tm1Doi
Genetic Background	involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74^tm1Doi mutation (1 available); any Cd74 mutation (37 available)
H2-DMa^tm1Luc mutation (1 available); any H2-DMa mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal level of surface class II molecules ( J:45185 )

• reduced level of surface class II molecules on B cells

increased susceptibility to parasitic infection ( J:45185 )

• increased susceptibility to Leishmania major infection

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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