Phenotypes Associated with This Genotype

Genotype
MGI:2665511

• Allelic Composition: Tg(Tcra,Tcrb)3Ayr/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell proliferation ( J:80775 )

• actively proliferating cells are lower in number than proliferating control cells

abnormal positive T cell selection ( J:125548 )

• positive selection of CD4+ T cells is significantly greater in the thymus compared to Tg(Tcra51-11.5,Tcrb51-11.5)AR206Ayr mice

abnormal lymphocyte anergy ( J:80775 )

• cells are hyporesponsive to antigenic peptide challenge

hematopoietic system

decreased T cell proliferation ( J:80775 )

• actively proliferating cells are lower in number than proliferating control cells

abnormal positive T cell selection ( J:125548 )

• positive selection of CD4+ T cells is significantly greater in the thymus compared to Tg(Tcra51-11.5,Tcrb51-11.5)AR206Ayr mice

cellular

decreased T cell proliferation ( J:80775 )

• actively proliferating cells are lower in number than proliferating control cells