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Phenotypes Associated with This Genotype
Genotype
MGI:2665134
Allelic
Composition		 Rag1tm1Mom/Rag1tm1Mom
Tg(LPV-TAg1135)11Tvd/0
Tg(TcrLCMV)327Sdz/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (56 available); any Rag1 mutation (133 available)
Tg(LPV-TAg1135)11Tvd mutation (0 available)
Tg(TcrLCMV)327Sdz mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:47667 )
• survival time at which half of the mutants are sacrificed or die due to illness is 101 days

neoplasm
increased T cell derived lymphoma incidence ( J:47667 )
• 100% of mutants develop thymic lymphoma within the same accelerated time frame as mutants heterozygous for Rag1 and hemizygous for the two transgenes

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:47667 )
• 100% of mutants develop thymic lymphoma within the same accelerated time frame as mutants heterozygous for Rag1 and hemizygous for the two transgenes

hematopoietic system
increased T cell derived lymphoma incidence ( J:47667 )
• 100% of mutants develop thymic lymphoma within the same accelerated time frame as mutants heterozygous for Rag1 and hemizygous for the two transgenes

immune system
increased T cell derived lymphoma incidence ( J:47667 )
• 100% of mutants develop thymic lymphoma within the same accelerated time frame as mutants heterozygous for Rag1 and hemizygous for the two transgenes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory