Phenotypes Associated with This Genotype

Genotype
MGI:2665126

• Allelic Composition: Rag1^tm1Mom/Rag1^tm1Mom; Tg(LPV-TAg1135)11Tvd/0
• Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:47667 )

• survival time at which half of the mutants are sacrificed or die due to illness is 238 days

neoplasm

increased T cell derived lymphoma incidence ( J:47667 )

• 85% incidence of thymoma

• tumors arise more slowly or with longer latency than in single hemizygous Tg(LPV-TAg1135)11Tvd mice, with mutants living 44% longer than controls

hematopoietic system

increased T cell derived lymphoma incidence ( J:47667 )

• 85% incidence of thymoma

• tumors arise more slowly or with longer latency than in single hemizygous Tg(LPV-TAg1135)11Tvd mice, with mutants living 44% longer than controls

abnormal T cell receptor V(D)J recombination ( J:47667 )

• inactive V(D)J recombination

immune system

increased T cell derived lymphoma incidence ( J:47667 )

• 85% incidence of thymoma

• tumors arise more slowly or with longer latency than in single hemizygous Tg(LPV-TAg1135)11Tvd mice, with mutants living 44% longer than controls

abnormal T cell receptor V(D)J recombination ( J:47667 )

• inactive V(D)J recombination

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:47667 )

• 85% incidence of thymoma

• tumors arise more slowly or with longer latency than in single hemizygous Tg(LPV-TAg1135)11Tvd mice, with mutants living 44% longer than controls