Phenotypes for Ret Wnt11 MGI:2665019 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Ret^tm1Cos/Ret⁺ Wnt11^tm1Amc/Wnt11^tm1Amc
Genetic Background	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * MF1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ret^tm1Cos mutation (2 available); any Ret mutation (53 available)
Wnt11^tm1Amc mutation (2 available); any Wnt11 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

small kidney ( J:83430 )

• kidneys are 44% the size of Wnt11-null kidneys and 67% the size of Ret,Wnt11 double heterozygotes

impaired branching involved in ureteric bud morphogenesis ( J:83430 )

• ureteric branching is severely affected at E12.5, much mores so than in Wnt11 null embryos

• kidneys only have 2-4 ureteric buds at E12.5 compared to the normal 7 in wild-type

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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