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Phenotypes Associated with This Genotype
Genotype
MGI:2664938
Allelic
Composition		 Gata4tm1Jml/Gata4tm1Jml
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4tm1Jml mutation (0 available); any Gata4 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart development ( J:40144 )
• E8.5 embryos lacked ventral pericardial cavity and heart tube
absent heart tube ( J:40144 )
• absent in E8.5 embryos

digestive/alimentary system
abnormal foregut morphology ( J:40144 )
• E10.5 embryos had defective gut tube formation

embryo
abnormal dorsal-ventral axis patterning ( J:40144 )
• defective ventral-dorsal folding
abnormal rostral-caudal axis patterning ( J:40144 )
• defective rostral-caudal folding
decreased embryo size ( J:40144 )
• embryos smaller than wild-type and heterozygous littermates
abnormal visceral yolk sac morphology ( J:40144 )
• defective closure of yolk sac at ventral surface of embryos

growth/size/body
decreased embryo size ( J:40144 )
• embryos smaller than wild-type and heterozygous littermates

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory