Phenotypes Associated with This Genotype

Genotype
MGI:2664729

• Allelic Composition: Cul3^tm1Jro/Cul3^tm1Jro
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:57761 )

• in embryos after E7.5, yolk sacs contained partially degenerating or fully resorbed embryos

embryo

abnormal gastrulation ( J:57761 )

• abnormal gastrulation with no clear evidence of embryonic mesoderm and endoderm

decreased embryo size ( J:57761 )

• embryos were substantially smaller than wild-type embryos (E6.5)

abnormal trophectoderm morphology ( J:57761 )

• abnormally developed trophectoderm

abnormal trophoblast giant cell morphology ( J:57761 )

• trophoblast cells have small nucleii; despite high levels of nuclear cyclin E in these cells, no S-phase cells were detected

absent amnion ( J:57761 )

abnormal extraembryonic ectoderm morphology ( J:57761 )

• greatly elevated frequency of cells in S-phase

disorganized extraembryonic tissue ( J:57761 )

• absence of the extraembryonic cavities

growth/size/body

decreased embryo size ( J:57761 )

• embryos were substantially smaller than wild-type embryos (E6.5)