Phenotypes Associated with This Genotype

Genotype
MGI:2664351

• Allelic Composition: Bmp4^tm2Blh/Bmp4^tm2Blh
• Genetic Background: involves: 129S6/SvEvTac * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:71204 )

• die at about E9.5

embryo

embryonic growth retardation ( J:53311 )

absent allantois ( J:53311 )

• all embryos lacked an allantois

reproductive system

absent primordial germ cells ( J:53311 )

• absent primordial germ cells

digestive/alimentary system

abnormal foregut morphology ( J:71204 )

• do not display thickening of the foregut endoderm at the 14-17 somite stage

• by the 20 somite stage some thickening is seen but a distinct liver bud has not developed

liver/biliary system

abnormal liver bud morphology ( J:71204 )

• by the 20 somite stage some thickening of the foregut endoderm is seen but a distinct liver bud has not developed

delayed hepatic development ( J:71204 )

• by the 20 somite stage a distinct liver bud has not formed

• however, initiation of albumin expression is detected

growth/size/body

embryonic growth retardation ( J:53311 )

cellular

absent primordial germ cells ( J:53311 )

• absent primordial germ cells