Phenotypes Associated with This Genotype

Genotype
MGI:2664349

• Allelic Composition: Bmp4^tm1Blh/Bmp4⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

decreased primordial germ cell number ( J:53311 , J:199855 )

• fewer PGCs due to a reduced founder population rather than impaired expansion (J:53311)

• estimated 62% reduction in PGC founder population of mice on the C57BL/6, CBA mixed background (J:53311)

• PGCs were absent in 9% of mutant mice on the C57BL/6, CBA mixed background (J:53311)

• fewer Dppa3+ primordial germ cells than in wild-type mice (J:199855)

behavior/neurological

circling ( J:159227 )

• in 22 of 60 of mice with bilateral lateral semicircular canal defects

hearing/vestibular/ear

abnormal lateral semicircular canal morphology ( J:159227 )

• Background Sensitivity: only 9% of mice exhibit abnormal semicircular canal on a mixed 129S2/SvPas, C57BL/6, and CBA background compared to 70% of females and 62% of males on a mixed 129S2/SvPas and C57BL/6 background

cellular

decreased primordial germ cell number ( J:53311 , J:199855 )

• fewer PGCs due to a reduced founder population rather than impaired expansion (J:53311)

• estimated 62% reduction in PGC founder population of mice on the C57BL/6, CBA mixed background (J:53311)

• PGCs were absent in 9% of mutant mice on the C57BL/6, CBA mixed background (J:53311)

• fewer Dppa3+ primordial germ cells than in wild-type mice (J:199855)