Phenotypes Associated with This Genotype

Genotype
MGI:2664000

• Allelic Composition: Fkbp6^tm1Pngr/Fkbp6^tm1Pngr
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

azoospermia ( J:83634 )

♂ • no spermatozoa were observed in the caudal epididymis or seminiferous tubules

abnormal spermatocyte morphology ( J:83634 )

♂ • apoptosis of spermatocytes, most prevalent 21 days after birth

arrest of male meiosis ( J:83634 )

♂ • arrest at pachytene stage

small testis ( J:83634 )

♂

male infertility ( J:83634 )

♂ • males are infertile; however, fertility and meiosis are normal in females and no alterations of hormone levels (testosterone, LH, FSH, or estradiol) were detected in male mice

endocrine/exocrine glands

small testis ( J:83634 )

♂

cellular

azoospermia ( J:83634 )

♂ • no spermatozoa were observed in the caudal epididymis or seminiferous tubules

abnormal spermatocyte morphology ( J:83634 )

♂ • apoptosis of spermatocytes, most prevalent 21 days after birth

arrest of male meiosis ( J:83634 )

♂ • arrest at pachytene stage