Phenotypes Associated with This Genotype

Genotype
MGI:2663890

• Allelic Composition: Fah^tm1Mgo/Fah^tm1Mgo
• Genetic Background: either: (involves: 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:16046 )

• all alive at birth, but none survived past 24h after birth

homeostasis/metabolism

increased circulating creatinine level ( J:16046 )

• kidney dysfunction, as evidenced by elevated plasma levels of creatinine

hypoglycemia ( J:16046 )

• developed hypoglycemia during first few hours after birth

abnormal circulating aspartate transaminase level ( J:16046 )

• increased plasma levels of liver enzyme, aspartate amino transaminase (AST), indicative of hepatocellular damage