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Phenotypes Associated with This Genotype
Genotype
MGI:2663794
Allelic
Composition
Gnrh1hpg/Gnrh1hpg
Genetic
Background
involves: 101/H * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnrh1hpg mutation (2 available); any Gnrh1 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• males exhbited a reduced distance
• arrested development
• though some follicles were observed in the early stages of antrum formation, most were arrested at the pre-antral phase
• arrested development
• arrested development
• testes located in the abdomen
• arrested development
• failure of vagina to open fully
• rarely advanced beyond the diplotene stage
• underdeveloped scrotum

endocrine/exocrine glands
• arrested development
• though some follicles were observed in the early stages of antrum formation, most were arrested at the pre-antral phase
• arrested development
• arrested development
• testes located in the abdomen

growth/size/body
• male specific decrease in body weight evident at 6 weeks of age, putatively due to testosterone deficiency

nervous system
N
• no abnormalities found

skeleton
N
• no craniofacial abnormalities

homeostasis/metabolism
• reduced levels in the pituitary in both males and females
• reduced levels in the pituitary in both males and females
• reduced levels in both males and females
• reduced levels in the pituitary in both males and females
• reduced levels in the pituitary in both males and females

renal/urinary system

digestive/alimentary system
• males exhbited a reduced distance

integument

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hypogonadotropic hypogonadism 12 with or without anosmia DOID:0090072 OMIM:614841
J:5877


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory