Phenotypes Associated with This Genotype

Genotype
MGI:2663640

• Allelic Composition: Pdgfra^{tm9(Pdgfra/Fgfr1)Sor}/Pdgfra⁺
• Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

ectopic cranial bone ( J:83560 )

• abnormal cranial bone development which results in bone growth in front of the developing eye

cleft palate ( J:83560 )

embryo

open neural tube ( J:83560 )

• failed ventral closure

spina bifida ( J:83560 )

enlarged placenta ( J:83560 )

• large placenta

abnormal trophoblast layer morphology ( J:83560 )

• trophoblast lineages are disorganized, as indicated by an expansion of the chorioallantoic layer into the surrounding labyrinth trophoblast layer

limbs/digits/tail

polydactyly ( J:83560 )

skeleton

ectopic cranial bone ( J:83560 )

• abnormal cranial bone development which results in bone growth in front of the developing eye

abnormal pubis morphology ( J:83560 )

• ectopic bone growth extending from the pubic bone and fusing, in most cases, to the elbow

rib fusion ( J:83560 )

nervous system

open neural tube ( J:83560 )

• failed ventral closure

spina bifida ( J:83560 )

digestive/alimentary system

cleft palate ( J:83560 )

growth/size/body

cleft palate ( J:83560 )