Phenotypes Associated with This Genotype

Genotype
MGI:2663350

• Allelic Composition: Clock^m1Jt/Clock⁺
• Genetic Background: C57BL/6-Clock^m1Jt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavior ( J:101849 )

• in a forced-swim test, female mice exhibit less immobility compared with wild-type mice but as much as in Clock^m1Jt homozygotes

• however, anxiety and depressive-like behavior are not increased

increased exploration in new environment ( J:101849 )

• during constant darkness in an open field, mice spend more time exploring the center than wild-type mice but as much as in Clock^m1Jt homozygotes

increased vertical activity ( J:101849 )

• in female mice in an open field test

prolonged circadian behavior period ( J:198519 , J:18005 )

• increased 0.6 hr upon exposure to constant darkness (J:198519)

• Background Sensitivity: mice on a C57BL/6J isogenic background exhibit a longer activity period under constant darkness than mice on a (BALB/cJ x C57BL/6J)F1 or BALB/cJ congenic background (J:198519)

• circadian period gradually lengthens over the first 39 days of constant darkness, with an average of 24.4 hours compared to 23.2 hours in wild-type (J:18005)

abnormal circadian behavior phase ( J:98343 )

• in constant darkness, mice exhibit a 1 hour increase in free-running rhythm of locomotor activity compared with wild-type mice

decreased sleep duration ( J:65198 )

• mice spend 9% less time asleep during the entire 24 hour light dark cycle compared with wild-type mice

abnormal sleep pattern ( J:65198 )

• during the 12 hour dark phase, mice spend less time in non-REM sleep than wild-type mice

• during the 12 hour dark phase, REM sleep is shorter than in wild-type mice