Phenotypes for Ercc8 Xpc MGI:2663268 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Ercc8^tm1Jhjh/Ercc8^tm1Jhjh Xpc^tm1Ecf/Xpc⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ercc8^tm1Jhjh mutation (0 available); any Ercc8 mutation (36 available)
Xpc^tm1Ecf mutation (1 available); any Xpc mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased incidence of tumors by UV-induction ( J:74959 )

• mutants develop skin tumors after chronic exposure to UVB radiation at an accelerated rate compared to single Ercc8 homozygotes

• mutants exposed to UVB radiation also develop eye tumors, most being hemangiosarcomas

homeostasis/metabolism

increased incidence of tumors by UV-induction ( J:74959 )

• mutants develop skin tumors after chronic exposure to UVB radiation at an accelerated rate compared to single Ercc8 homozygotes

• mutants exposed to UVB radiation also develop eye tumors, most being hemangiosarcomas

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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