Phenotypes Associated with This Genotype

Genotype
MGI:2662584

• Allelic Composition: Chl1^tm1Mtg/Chl1^tm1Mtg
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:79902 )

N • Background Sensitivity: mutants on a mixed 129P2/OlaHsd and C57BL/6 background do not show enlargement of the lateral ventricles until they have been backcrossed to C57BL/6 for 10 generations

abnormal olfactory sensory neuron morphology ( J:79902 )

• some olfactory neurons project to two glomeruli or pass through the glomerular layer and terminate in the external plaxiform instead of terminating in the olfactory bulb glomeruli as in wild-type

• arborizations of some olfactory axons are not restricted to a glomerulus, delimited by the periglomerular cell populations, but extend outside this cellular border

abnormal hippocampal mossy fiber morphology ( J:79902 )

• mossy fiber organization is altered, with some axons forming small bundles or traveling as individual thin mossy fibers through the CA3 region, forming a network between the suprapyramidal and infrapyramidal bundles

abnormal olfactory neuron innervation pattern ( J:79902 )

• projection pattern of some sensory olfactory neurons is altered in the olfactory bulb

craniofacial

abnormal olfactory sensory neuron morphology ( J:79902 )

• some olfactory neurons project to two glomeruli or pass through the glomerular layer and terminate in the external plaxiform instead of terminating in the olfactory bulb glomeruli as in wild-type

• arborizations of some olfactory axons are not restricted to a glomerulus, delimited by the periglomerular cell populations, but extend outside this cellular border

respiratory system

abnormal olfactory sensory neuron morphology ( J:79902 )

• some olfactory neurons project to two glomeruli or pass through the glomerular layer and terminate in the external plaxiform instead of terminating in the olfactory bulb glomeruli as in wild-type

• arborizations of some olfactory axons are not restricted to a glomerulus, delimited by the periglomerular cell populations, but extend outside this cellular border

taste/olfaction

abnormal olfactory sensory neuron morphology ( J:79902 )

• some olfactory neurons project to two glomeruli or pass through the glomerular layer and terminate in the external plaxiform instead of terminating in the olfactory bulb glomeruli as in wild-type

• arborizations of some olfactory axons are not restricted to a glomerulus, delimited by the periglomerular cell populations, but extend outside this cellular border

growth/size/body

abnormal olfactory sensory neuron morphology ( J:79902 )

• some olfactory neurons project to two glomeruli or pass through the glomerular layer and terminate in the external plaxiform instead of terminating in the olfactory bulb glomeruli as in wild-type

• arborizations of some olfactory axons are not restricted to a glomerulus, delimited by the periglomerular cell populations, but extend outside this cellular border