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Phenotypes Associated with This Genotype
Genotype
MGI:2662540
Allelic
Composition		 Cebpgtm1Aki/Cebpgtm1Aki
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cebpgtm1Aki mutation (0 available); any Cebpg mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:58801 )
• only 11% of animals survive past 60 hours after birth

immune system
abnormal NK cell physiology ( J:58801 )
• natural killer cells from newborns exhibit impaired IFN-gamma production when stimulated with IL-12 plus IL-18
impaired natural killer cell mediated cytotoxicity ( J:58801 )
• IL-15 induced natural killer cells generated from mutant spleens show impaired cytotoxic activity against YAC-1 cells

respiratory system
overexpanded pulmonary alveolus ( J:58801 )
• at 24 hours after birth, mutants exhibit emphysematous changes in the lungs

hematopoietic system
abnormal NK cell physiology ( J:58801 )
• natural killer cells from newborns exhibit impaired IFN-gamma production when stimulated with IL-12 plus IL-18
impaired natural killer cell mediated cytotoxicity ( J:58801 )
• IL-15 induced natural killer cells generated from mutant spleens show impaired cytotoxic activity against YAC-1 cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory