Phenotypes Associated with This Genotype

Genotype
MGI:2662512

• Allelic Composition: Cdx1^tm1Pgr/Cdx1^tm1Pgr
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal occipital bone morphology ( J:29755 )

abnormal basioccipital bone morphology ( J:29755 )

• broader at the posterior end and in most homozygotes, incomplete neural arches are fused to it

abnormal exoccipital bone morphology ( J:29755 )

• the occipital condyles of the exoccipital bone are not well developed

broad supraoccipital bone ( J:29755 )

• occasionally, the supraoccipital bone is broader

rib fusion ( J:29755 )

• R1 and R2 are fused unilaterally in 28% and bilaterally in 35% of mice

vertebral transformation ( J:29755 )

• anterior homeotic transformation of vertebrae, with the first vertebra developing into a more anterior structure, the basioccipital bone, and subsequent vertebrae up to the posterior thoracic ones assuming anterior identities; penetrance varies somewhat with background

craniofacial

abnormal occipital bone morphology ( J:29755 )

abnormal basioccipital bone morphology ( J:29755 )

• broader at the posterior end and in most homozygotes, incomplete neural arches are fused to it

abnormal exoccipital bone morphology ( J:29755 )

• the occipital condyles of the exoccipital bone are not well developed

broad supraoccipital bone ( J:29755 )

• occasionally, the supraoccipital bone is broader

embryo

abnormal embryonic erythropoiesis ( J:136405 )

• hematopoietic progenitor formation is reduced in cells derived from day 6 erythroid bodies

• but no impairment in yolk sac hematopoiesis is detected

hematopoietic system

abnormal embryonic erythropoiesis ( J:136405 )

• hematopoietic progenitor formation is reduced in cells derived from day 6 erythroid bodies

• but no impairment in yolk sac hematopoiesis is detected